Possible side effects with
LYTGOBI® (futibatinib)
You may experience side effects during treatment
Talk to your healthcare provider if you notice anything out of the ordinary with your health while taking LYTGOBI.
Serious side effects with LYTGOBI include eye problems* and high phosphate levels in your blood.† Below is a list of some of the additional possible side effects of LYTGOBI:
- Nails separated from the bed or poor formation of the nail
- Change in the color of nails
- Muscle pain
- Constipation
- Diarrhea
- Feeling tired or weak
- Dry mouth
- Hair loss
- Mouth sores
- Stomach area (abdominal) pain
- Dry skin
- Joint pain
- Changes in sense of taste
- Dry eye
- Nausea
- Decrease in appetite
- Urinary tract infection
- Redness, swelling, peeling or tenderness, mainly on the hands or feet (hand-foot syndrome)
- Vomiting
Your healthcare provider may use blood tests and other laboratory tests to monitor possible side effects such as changes in kidney or liver function, increased blood glucose level, and decreased red blood cell, white blood cell, and platelet counts.‡
These are not all the possible side effects of LYTGOBI.
- *You will need to see an eye specialist for a complete eye exam before you begin treatment with LYTGOBI, every 2 months for the first 6 months, and every 3 months thereafter during treatment with LYTGOBI. Please see the full Prescribing Information for instructions.
- †Tell your healthcare provider right away if you develop any muscle cramps, or numbness or tingling around your mouth as this is a more serious side effect.
- ‡See the Prescribing Information for a full list of possible side effects that your healthcare provider will monitor with blood tests.
Tips to help manage some common side effects
You should always talk to your healthcare provider about any side effects you experience. Your healthcare provider will know the best way to help manage side effects, including prescribing an additional medication, lowering your dose of LYTGOBI, or temporarily or completely stopping treatment with LYTGOBI.
Some side effects can be managed at home. In addition to your healthcare provider's advice, here are some tips to help manage some of the common side effects of LYTGOBI.
- Try eating smaller meals throughout the day instead of 3 large meals
- Eat foods that are low in fiber and high in sodium or potassium. You can ask your healthcare provider for suggestions on specific foods
- Contact your healthcare provider if your diarrhea lasts more than 24 hours, or if you have pain or cramping
- Sip water throughout the day, suck on ice chips and sugar-free candy, or chew sugar-free gum
- If your mouth is always dry, ask your healthcare provider about saliva substitutes
- Be gentle when you wash your hair; use mild shampoo and pat dry
- Avoid items that can hurt your scalp such as heat-powered styling tools, hairspray or hair dye, or hair bands and clips
- Protect your scalp during and after hair loss by wearing a hat, turban, or scarf while you are outside, and avoid extreme temperatures
- Use a satin pillowcase to avoid friction while sleeping
- Take quick showers or sponge baths using a mild, moisturizing soap
- Pat yourself dry and apply moisturizing lotion while your skin is still damp after bathing
- Avoid toiletries containing alcohol
- Try to be active every day by walking or doing light exercise
- Eat foods that are high in fiber, such as whole-grain breads and cereals. You can also ask your healthcare provider for suggestions on specific foods
- Talk to your healthcare provider if you do not have a bowel movement for 2 days. They may suggest a fiber supplement, laxative, stool softener, or enema. Do not use these treatments without your healthcare provider's approval
- Try relaxing activities like meditation or yoga
- Plan time to rest during the day
- Try to get at least 8 hours of sleep at night
- Try low-effort exercises like short walks to stay active
Healthy Reminder: Try to eat well and drink at least 8 cups of water or other fluids each day.
WHAT IS LYTGOBI?
LYTGOBI is a prescription medicine that is used to treat adults with bile duct cancer (intrahepatic cholangiocarcinoma) that has spread or cannot be removed by surgery, who have already received a previous treatment, and whose tumor has a certain type of abnormal “FGFR2” gene.
Your healthcare provider will test your cancer for a certain type of abnormal FGFR2 gene and make sure that LYTGOBI is right for you.
It is not known if LYTGOBI is safe and effective in children.
LYTGOBI is approved based on tumor response and duration of response. There are ongoing studies to show if LYTGOBI improves survival or symptoms.
IMPORTANT SAFETY INFORMATION
LYTGOBI may cause serious side effects, including:
- Eye problems: Certain eye problems are common with LYTGOBI but can also be serious. Eye problems include dry or inflamed eyes, inflamed cornea (front part of the eye), increased tears, and a disorder of the retina (an internal part of the eye). You will need to see an eye specialist for a complete eye exam before you begin treatment with LYTGOBI, every 2 months for the first 6 months, and every 3 months thereafter during treatment with LYTGOBI.
- Tell your healthcare provider right away if you develop any changes in your vision during treatment with LYTGOBI, including blurred vision, flashes of light, or seeing black spots. You may need to see an eye specialist right away.
- You should use artificial tears or substitutes, or hydrating or lubricating eye gels during treatment with LYTGOBI to help prevent or treat dry eyes.
- High phosphate levels in your blood (hyperphosphatemia) and buildup of minerals in different tissues in your body: Hyperphosphatemia is common with LYTGOBI but can also be serious. High levels of phosphate in your blood may lead to buildup of minerals such as calcium in different tissues in your body. Your healthcare provider will check your blood phosphate levels during treatment with LYTGOBI.
- Your healthcare provider may prescribe changes in your diet or phosphate-lowering therapy, or change, interrupt, or stop LYTGOBI if needed.
- Tell your healthcare provider right away if you develop any muscle cramps, or numbness or tingling around your mouth.
The most common side effects of LYTGOBI include:
- changes in kidney function blood tests
- increased blood glucose level
- decreased red blood cell, white blood cell, and platelet counts
- increased calcium level in the blood
- decreased sodium and phosphate levels in the blood
- changes in liver function blood tests
- nails separate from the bed or poor formation of the nail; change in the color of nails
- muscle pain
- constipation
- diarrhea
- feeling tired or weak
- changes in tests used to measure your blood clotting time
- dry mouth
- hair loss
- decreased protein level (albumin) in the blood
- mouth sores
- stomach area (abdominal) pain
- dry skin
- decreased glucose and potassium level in the blood
- joint pain
- changes in sense of taste
- dry eye
- nausea
- decrease in appetite
- urinary tract infection
- redness, swelling, peeling or tenderness, mainly on the hands or feet (“hand-foot syndrome”)
- vomiting
These are not all the possible side effects of LYTGOBI. For more information, talk to your healthcare provider or pharmacist. You may report side effects to FDA at 1-800-FDA-1088.
Before you take LYTGOBI, tell your healthcare provider about all of your medical conditions, including if you:
- have vision or eye problems.
- are pregnant or plan to become pregnant. LYTGOBI can harm your unborn baby or cause loss of your pregnancy (miscarriage). You should not become pregnant during treatment with LYTGOBI.
- Females who can become pregnant:
- Your healthcare provider should do a pregnancy test before you start treatment with LYTGOBI.
- You should use an effective method of birth control during treatment and for 1 week after your final dose of LYTGOBI. Talk to your healthcare provider about birth control methods that may be right for you.
- Tell your healthcare provider right away if you become pregnant or think that you may be pregnant.
- Males with female partners who can become pregnant:
- You should use effective birth control when sexually active during treatment with LYTGOBI and for 1 week after your last dose of LYTGOBI.
- are breastfeeding or plan to breastfeed. It is not known if LYTGOBI passes into your breast milk. Do not breastfeed during treatment and for 1 week after your last dose of LYTGOBI.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. LYTGOBI and other medicines may affect each other causing side effects. LYTGOBI may affect the way other medicines work, and other medicines may affect how LYTGOBI works.
WHAT IS LYTGOBI?
LYTGOBI is a prescription medicine that is used to treat adults with bile duct cancer (intrahepatic cholangiocarcinoma) that has spread or cannot be removed by surgery, who have already received a previous treatment, and whose tumor has a certain type of abnormal “FGFR2” gene.
Your healthcare provider will test your cancer for a certain type of abnormal FGFR2 gene and make sure that LYTGOBI is right for you.
It is not known if LYTGOBI is safe and effective in children.
LYTGOBI is approved based on tumor response and duration of response. There are ongoing studies to show if LYTGOBI improves survival or symptoms.
IMPORTANT SAFETY INFORMATION
LYTGOBI may cause serious side effects, including:
- Eye problems: Certain eye problems are common with LYTGOBI but can also be serious. Eye problems include dry or inflamed eyes, inflamed cornea (front part of the eye), increased tears, and a disorder of the retina (an internal part of the eye). You will need to see an eye specialist for a complete eye exam before you begin treatment with LYTGOBI, every 2 months for the first 6 months, and every 3 months thereafter during treatment with LYTGOBI.
- Tell your healthcare provider right away if you develop any changes in your vision during treatment with LYTGOBI, including blurred vision, flashes of light, or seeing black spots. You may need to see an eye specialist right away.
- You should use artificial tears or substitutes, or hydrating or lubricating eye gels during treatment with LYTGOBI to help prevent or treat dry eyes.
- High phosphate levels in your blood (hyperphosphatemia) and buildup of minerals in different tissues in your body: Hyperphosphatemia is common with LYTGOBI but can also be serious. High levels of phosphate in your blood may lead to buildup of minerals such as calcium in different tissues in your body. Your healthcare provider will check your blood phosphate levels during treatment with LYTGOBI.
- Your healthcare provider may prescribe changes in your diet or phosphate-lowering therapy, or change, interrupt, or stop LYTGOBI if needed.
- Tell your healthcare provider right away if you develop any muscle cramps, or numbness or tingling around your mouth.
The most common side effects of LYTGOBI include:
- changes in kidney function blood tests
- increased blood glucose level
- decreased red blood cell, white blood cell, and platelet counts
- increased calcium level in the blood
- decreased sodium and phosphate levels in the blood
- changes in liver function blood tests
- nails separate from the bed or poor formation of the nail; change in the color of nails
- muscle pain
- constipation
- diarrhea
- feeling tired or weak
- changes in tests used to measure your blood clotting time
- dry mouth
- hair loss
- decreased protein level (albumin) in the blood
- mouth sores
- stomach area (abdominal) pain
- dry skin
- decreased glucose and potassium level in the blood
- joint pain
- changes in sense of taste
- dry eye
- nausea
- decrease in appetite
- urinary tract infection
- redness, swelling, peeling or tenderness, mainly on the hands or feet (“hand-foot syndrome”)
- vomiting
These are not all the possible side effects of LYTGOBI. For more information, talk to your healthcare provider or pharmacist. You may report side effects to FDA at 1-800-FDA-1088.
Before you take LYTGOBI, tell your healthcare provider about all of your medical conditions, including if you:
- have vision or eye problems.
- are pregnant or plan to become pregnant. LYTGOBI can harm your unborn baby or cause loss of your pregnancy (miscarriage). You should not become pregnant during treatment with LYTGOBI.
- Females who can become pregnant:
- Your healthcare provider should do a pregnancy test before you start treatment with LYTGOBI.
- You should use an effective method of birth control during treatment and for 1 week after your final dose of LYTGOBI. Talk to your healthcare provider about birth control methods that may be right for you.
- Tell your healthcare provider right away if you become pregnant or think that you may be pregnant.
- Males with female partners who can become pregnant:
- You should use effective birth control when sexually active during treatment with LYTGOBI and for 1 week after your last dose of LYTGOBI.
- are breastfeeding or plan to breastfeed. It is not known if LYTGOBI passes into your breast milk. Do not breastfeed during treatment and for 1 week after your last dose of LYTGOBI.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. LYTGOBI and other medicines may affect each other causing side effects. LYTGOBI may affect the way other medicines work, and other medicines may affect how LYTGOBI works.